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ey0015.15-12 | Obesity must be studied separately in men and women | ESPEYB15

15.12 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

C Wang , Y He , P Xu , Y Yang , K Saito , Y Xia , X Yan , A Hinton Jr , C Yan , H Ding

To read the full abstract: Nature Communications 2018;9:1544Obesity prevalence is generally higher in women than in men, and there is also a sex difference in body fat distribution. Sex differences in obesity can be explained in part by the influence of gonadal steroids on body composition and appetite; however, behavioural, and socio-cultural factors may also play a role. Here is th...

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ey0015.10-1 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

MJ Redondo , S Geyer , AK Steck , J Sosenko , M Anderson , P Antinozzi , A Michels , J Wentworth , P Xu , A Pugliese , T1DM TrialNet Study Group

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...

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ey0016.11-3 | New Insights into Body Weight Regulation | ESPEYB16

11.3. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Y Yang , AA van der Klaauw , L Zhu , TM Cacciottolo , Y He , LKJ Stadler , C Wang , P Xu , K Saito , A Jr. Hinton , X Yan , JM Keogh , E Henning , MC Banton , AE Hendricks , EG Bochukova , V Mistry , KL Lawler , L Liao , J Xu , S O'Rahilly , Q Tong , UK10K Consortium , I Barroso , BW O'Malley , IS Farooqi , Y Xu

To read the full abstract: Nat Comm 2019; 10(1): 1718Steroid receptor coactivator (SRC)-1 mediates nuclear hormone receptors and transcription factor-dependent transcription (1), and interacts with STAT3 (2) an important mediator of leptin-induced POMC expression and hence satiety (3). Src-1 knockout mice are obese (4), however, the underlying mechanism is unclear. In a...

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ESPE Yearbook of Paediatric Endocrinology

15.12 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

11.3. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

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